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KMID : 0882420210960020101
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Korean Journal of Medicine
2021 Volume.96 No. 2 p.101 ~ p.109
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Fever of Unknown Origin: An Overview of the Diagnostic Approach
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Kim Eun-Jin
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Abstract
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Although fever of unknown origin (FUO) was first defined in 1961, it remains a diagnostic challenge. The revised 1991 definition categorized FUO into classic FUO, nosocomial FUO, neutropenic FUO, and human immunodeficiency virus-related FUO, each requiring at least three outpatient visits or 3 days of in-hospital stay. The causes of classic FUO differ greatly geographically and temporally, and are divided into infections, noninfectious inflammatory diseases, neoplasms, and miscellaneous diseases. A systematic, comprehensive and rational approach is required for appropriate diagnosis. A medical history and physical examination are very important; they may reveal diagnostic clues. Here, we review the literature on the causes and diagnostic approaches of classical FUO.
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KEYWORD
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Fever of unknown origin, Diagnosis, 18FDG-PET/CT
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